橡胶技术网

合成橡胶工业
CHINA SYNTHETIC RUBBER INDUSTRY
2005 Vol.28 No.2 P.151-154

橡胶技术网

功能聚氨酯材料在生物医学工程中的研究进展及应用

Research development and application on modified functional polyurethane in biomedical engineering

眭建军  陈莉  陈苏 

摘 要:讨论了提高聚氨酯材料生物相容性和生物稳定性的改性方法,如表面活性端基改性、表面接枝聚合、表面形成互穿网络、使用表面活性剂、与纳米无机材料共混,介绍了功能性聚氨酯材料在生物医学工程中的应用及研究进展,表明聚氨酯材料的功能化改性仍然是今后的发展方向.
关键词:聚氨酯;生物相容性; 生物稳定性;改性; 医学应用
分类号:TQ333.95 文献标识码:A

文章编号:1000-1255(2005)02-0151-04

作者简介:眭建军(1973-)男,硕士生.已发表论文4篇.陈苏,通讯联系人.
作者单位:眭建军(南京工业大学,化学化工学院,江苏,南京,210009) 
     陈莉(南京工业大学,化学化工学院,江苏,南京,210009) 
     陈苏(南京工业大学,化学化工学院,江苏,南京,210009) 

参考文献:

[1]Chandran K B, Kim S H, Han G. Stress distribution on the cusps of a polyurethane trileaflet heart valve prosthesis in the closed position [J]. Biomech, 1991, 24(6): 385~395
[2]Min B G, Kim H C, Lee S H,et al. A moving-actuator type electromechanical total artificial heart(I): Linear type and mock circulation experiments [J]. IEEE Transactions on Biomedical Engineering, 1990, 37(12): 1 186~1 194
[3]Szycher M, Poirier V, Dempsey D. Synthrsis and fabrication of polyurethane elastomers for cardiac assist devices[C]. Boston:American Society of Mechanical Engineers, Applied Mechanics Division, 1979, 743~747
[4]Kaibara M, Kawamoto Y, Yanagida S, et al. In vitro evaluation of antithrombogenicity of hybrid-type vascular vessel models based on analysis of the mechanism of blood coagulation [J].Biomaterials, 1995, 16(16): 1 229~1 234
[5]Crabtree J H. Clinical biodurability of aliphatic polyether based polyurethanes as peritoneal dialysis catheters [J]. ASAIO Journal, 2003, 49(3): 290~294
[6]Blamey J, Rajan S, Unsworth A, et al. Soft layered prostheses for arthritic hip joints: a study of materials degradation [J]. Biomed Eng, 1991, 13(3): 180~184
[7]Sawae Y, Murakami T, Higak H, et al. Frictional behavior of artificial cartilage materials lubricated with synovia constituents [J]. Nippon Kikai Gakkai Ronbunshu, Part C, 1995, 61(589): 3 665~3 671
[8]Jones D S, Bonne M C, Gorman S P, et al. Sequential polyurethane-poly(methylmethacrylate) interpenetrating polymer networks as ureteral biomaterials: Mechanical properties and comparative resistance to urinary encrustation[J]. Materi Sci, Mater in Medi, 1997, 8(11): 713~717
[9]Murayama T, McMillin C R. Dynamic mechanical properties of elastomers for use in circulatory assist devices[J] Appl Polym Sci, 1983, 28(6): 1 871~1 877
[10]Parins D J,Black K M,Mccoy K D,et al.In vivo degradation of a polyurethane cardiac pacemakers[M].Minnesota:St.Paul.Inc,1981
[11]Tobiesen F A, Michielsen S. Method for grafting poly(acrylic acid) onto nylon 6,6 using amine end groups on nylon surface[J]. Polym Sci, Part A: Polymer Chemistry, 2002, 40(5): 719~728
[12]Ward R S, White K A. Surface-modifying endgroups for biomedical polymers [P]). US, US 5589563. 1996
[13]Ward R S, Tian Y, White K. Thermoplastic silicone-urethane copolymers: A new class of biomedical elastomers [C]. Boston:In 216th National Meeting for the American Chemical Society, 1998, 23~27
[14]Shen Y R, Chen Z, Ward R, et al. Interaction of fibrinogen with surfaces of end-group-modified polyurethanes: A surface-specific sum-frequency-generation vibrational spectroscopy study[J]. Biomed Mater Research, 2002, 62(2): 254~264
[15]Hsu S H, Chen W C. Improved cell adhesion by plasma-induced grafting of L-lactide onto polyurethane surface [J].Biomaterials, 2000, 21(4): 359~367
[16]Yuan Y L, Al F, Zhang J, et al. Grafting sulfobetaine monomer onto the segmented poly(ether-urethane) surface to improve hemocompatibility[J]. Biomater Sci-Polym Edition, 2002, 13 (10): 1 081~1 092
[17]Morimoto N, Iwasak Y, Nakabayashi N, et al. Physical properties and blood compatibility of surface-modified segmented polyurethane by semi-interpenetrating polymer networks with a phospholipid polymer[J].Biomaterials, 2002, 23(24): 4 881~ 4 887
[18]Wang D A, Feng L X, Ji J, et al. Novel human endothelial cell-engineered polyurethane biomaterials for cardiovascular biomedical applications[J]. Journal of Biomedical Materials Research ,Part A, 2003, 65(4): 498~510
[19]Brunstedt M R, Ziats N P, Rose C V, et al. Attachment and proliferation of bovine aortic endothelial cells onto additive modified poly(ether urethane ureas)[J]. Biomed Mater Res, 1993, 27(4): 483~492
[20]Niklasson G A, Klasson J, Olsson E. Polaron absorption in tungsten oxide nanoparticle aggregates[J].Electrochem Acta Massachusettsi, 2001, 46(13): 1 967~1 971
[21]Barbara B, Wernsdorfer W, Orozco E, et al. Submicron to nanometer size single particle measurements[C]. Massachusetts:Materials Research Society Symposium-Proceeding, 1997, 81: 265~276
[22]Lim Y T, Lee T W, Lee H C, et al. Enhanced photo-stability of conjugated polymer nanocomposites doped with functionalized nanoparticles[J]. Opt Mater, 2003, 21(1):585~589
[23]孔桦,许海燕,蔺嫦燕,等. 纳米碳改性聚氨酯复合材料的表面抗凝血性能[J].基础医学与临床,2002,22(2),113~116
[24]Xu R J, Manias E, Snyder A J, et al. Low permeability biomedical polyurethane nanocomposites[J]. Biomed Mater Res Part A, 2003, 64(1): 114~119

收稿日期:2004年3月9日

修稿日期:2004年11月13日

出版日期:2005年3月15日